A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer

Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of β-cyclodextrin linked with multiple arms of N,N-diisopropylethylenediamin...

متن کامل

Cancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis

Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. ...

متن کامل

Cancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis

Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. ...

متن کامل

Cardiac Metastasis of Breast Cancer: A Case Report

Breast cancer is one of the most common cancers in women. As we know, cardiac metastases occur rarely. In this study, a 40-year-old woman referred to the hospital due to severe pain in the right leg. She was diagnosed with deep vein thrombosis (DVT) and received treatment, but, after one month and a half she returned with severe pain, exacerbated shortness of breath, cramping pain, and chest pa...

متن کامل

Supporting Information Lysosome-Controlled Efficient ROS Overproduction against Cancer Cells with High pH-Responsive Catalytic Nanosystem

Experimental section Materials Cetyltr imethyl ammonium bromide (C16TAB), tetraethyl orthosilicate (TEOS), Fe3O4 NPs (ca. 20 nm) and 3,3',5,5'-tetramethylbenzidine (TMB) were obtained from Aladdin. Titanium potassium oxalate (K2TiO(C2O4)2·2H2O), hydrogen peroxide (H2O2, 30%) and potassium ferricyanide were purchased from Sinopharm Chemical Reagent Co., Ltd. Potassium ferrate (K2FeO4), 3-aminopr...

متن کامل

A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer

نویسندگان

چکیده

منابع مشابه